Funding opportunities directory
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RFA-OD-25-008: Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional) — Historical Reference
Historical reference for the closed NIH and FDA Tobacco Regulatory Science Small Grant Program for New Investigators, an R03 opportunity for early-career biomedical, behavioral, and social science investigators.
RFA-NS-27-015: BRAIN Initiative Connectivity Across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)
NIH's BRAIN Initiative NOFO supports U01 cooperative agreement projects that build scalable technologies for brain-wide connectivity mapping, with an estimated $10M commitment in the first year and approximately 3–6 awards expected.
RFA-NS-25-017: BRAIN Initiative—Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System
Historical NIH BRAIN Initiative U01 funding opportunity for optimizing instrumentation and device technologies for neural recording and modulation. The final receipt date was June 15, 2026, and the NOFO expired June 16, 2026; no successor cycle is announced on the official notices reviewed.
RFA-MH-27-205: Single Source: Accelerating Medicines Partnership Schizophrenia DPACC
The National Institute of Mental Health published a closed single-source U24 cooperative agreement for Brigham and Women's Hospital to continue the AMP Schizophrenia Data Processing, Analysis, and Coordination Center. The FY2027 cycle had one $5,000,000 award and a June 9, 2026 application deadline.
RFA-MH-26-170: BRAIN Initiative - Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01)
NIH BRAIN Initiative reissue NOFO for R01 projects that develop and validate high-impact tools for precise, cell- and circuit-specific neuroscience research without clinical trials.
RFA-JG-26-034: Enhancing Understanding and Preparedness for Public Health Threats Through Research in Kenya
A CDC cooperative agreement to support research, implementation science, and public-health evaluations in Kenya across four required priority areas, while strengthening local research capacity and systems for disease detection, prevention, and response.
RFA-HL-27-004: Limited Competition: Small Grant Program for NHLBI K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)
NIH’s NHLBI RFA-HL-27-004 is a limited-competition R03 small grant opportunity to help current and recently completed NHLBI K01/K08/K23/K25 awardees advance toward independent funding through a short, NIH-funded pilot- to proof-of-concept scale project.
RFA-HL-26-019: Catalyze Product Definition - Medical Device Prototype Design/Testing and Disease Target Identification and Assay Development (R61/R33; Clinical Trial Not Allowed)
NIH NHLBI Catalyze Product Definition NOFO for early-stage device, diagnostic, and research-tool development in heart, lung, blood, and sleep diseases. The next new-application due date is October 21, 2026.
RFA-HL-26-018: Catalyze Product Definition for Small Molecules, Biologics, and Combination Products
An NIH R33 Catalyze Product Definition NOFO for early translational work that identifies a lead compound series and tests a combination-product prototype for heart, lung, blood, and sleep diseases. The next announced application date is October 21, 2026.
RFA-HL-26-016: Catalyze Enabling Technologies and Transformative Platforms for HLBS Research (R33)
The National Heart, Lung, and Blood Institute's Catalyze R33 supports further development and rigorous validation of transformative, multi-use technologies and platforms relevant to heart, lung, blood, and sleep research. The next listed application due date is 2026-10-21.
RFA-HL-26-002: NHLBI Outstanding Investigator Award (OIA) (R35 Clinical Trial Optional)
The NHLBI Outstanding Investigator Award provides up to 7 years of flexible R35 support, with applications requesting up to $700,000 in direct costs per year, for established investigators whose programs advance heart, lung, blood, and sleep research.
RFA-ES-25-002: Environmental Health Sciences Core Centers Program (P30 Clinical Trials Optional)
The National Institute of Environmental Health Sciences invites U.S. applicants to propose Environmental Health Sciences Core Centers through the P30 mechanism. The next listed application due date is April 20, 2027.
RFA-DK-27-126: Kidney, Urologic, and Hematologic Diseases - Fostering the AdvanceMent of an Interactive Learning communitY - Coordinating Center (KUH-FAMILY) (U24 - Clinical Trials Not Allowed)
A completed NIH/NIDDK cooperative-agreement opportunity for one coordinating center to unite KUH training programs, support career development, and administer a national peer-to-peer research community.
RFA-DE-27-002: Accelerating Product Excellence in Innovation and for Clinical Adoption (APEx) (U24 Clinical Trial Not Allowed)
NIH Notice of Funding Opportunity for one U24 Resource Center and associated Interdisciplinary Translational Projects to advance tissue engineering and regenerative medicine products through preclinical development toward clinical adoption.
RFA-DC-27-004: BRAIN Initiative Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61)
NIH BRAIN Initiative award for exploratory human neuroscience using direct intracranial recording with or without stimulation, with clinical trials not allowed, up to $700,000 in direct costs per year and a 3-year maximum project period.
RFA-DC-26-001: Early-Stage Dissemination and Implementation Research in Communication Disorders (R21 Clinical Trial Optional)
NIH's NIDCD reissue supports early-stage dissemination and implementation (D&I) research that prepares evidence-based communication-disorder interventions for real-world use through a two-year, R21-format mechanism. The next listed application deadline is June 17, 2027.
RFA-DC-25-005: In Vivo High-Resolution Imaging for Inner Ear Visualization (R01, Clinical Trial Optional)
This NIH NIDCD R01 NOFO supports higher-resolution structural or functional imaging for the living human inner ear, including eligible low-risk clinical trials, with a per-grant direct-cost limit and a five-year maximum project period.
RFA-DC-25-003: Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01, Clinical Trial Required)
NIH/NIDCD funding for investigator-initiated high-risk clinical trials that develop in vivo high-resolution structural and functional imaging technologies for the living human inner ear and support translation into clinical care.
RFA-DA-26-056: Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)
NIDA's RFA-DA-26-056 funds R21 projects that use existing social, behavioral, administrative, and neuroimaging data to study substance use, related disorders, prevention, HIV, and service use without new data collection.
RFA-DA-26-055: Accelerating the Pace of Substance Use Research Using Existing Data (R01)
NIH’s NIDA RFA-DA-26-055 supports R01 projects that use existing social, behavioral, administrative, and neuroimaging datasets to advance prevention, treatment, and service-delivery research on substance use, HIV, and related outcomes, without collecting primary data.
RFA-CA-27-021: Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)
The National Cancer Institute's RFA-CA-27-021 supports continued operations and improvement of existing, widely adopted informatics tools and resources for cancer research, with awards capped at $600,000 in direct costs per year for up to five years.
RFA-AI-27-016: Tuberculosis Research Advancement Centers (TRACs) (P30, Clinical Trial Not Allowed)
Historical NIH/NIAID center-grant opportunity for Tuberculosis Research Advancement Centers. The 2026 cycle closed on July 10, 2026; no subsequent cycle is announced on the official record checked.
RFA-AI-27-012: Coccidioidomycosis Collaborative Research Centers (P01 Clinical Trial Not Allowed)
NIH/NIAID’s RFA-AI-27-012 established a closed, one-time Coccidioidomycosis Collaborative Research Centers competition focused on Valley fever vaccine research, with 3-4 P01 awards intended for FY 2027.
RFA-AG-26-011: NIA Expanding Research in AD/ADRD (ERA) Summer Research Education Program (R25 Independent Clinical Trial Not Allowed)
The National Institute on Aging invites R25 applications for intensive summer research education in Alzheimer's disease and related dementias for high school students, undergraduates, or science teachers. The next listed application due date is May 26, 2027.
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